Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks.

Psychosom Med. 2012 Nov-Dec;74(9):904-11. doi: 10.1097/PSY.0b013e318273bf33. Epub 2012 Oct 31.

Sripada RK1, King AP, Welsh RC, Garfinkel SN, Wang X, Sripada CS, Liberzon I.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498527/

Advertisements

ALTERED DEFAULT MODE NETWORK (DMN) RESTING STATE FUNCTIONAL CONNECTIVITY FOLLOWING A MINDFULNESS-BASED EXPOSURE THERAPY FOR POSTTRAUMATIC STRESS DISORDER (PTSD) IN COMBAT VETERANS OF AFGHANISTAN AND IRAQ.

Depress Anxiety. 2016 Apr;33(4):289-99. doi: 10.1002/da.22481.

King AP1,2, Block SR1,2,3, Sripada RK2,4, Rauch S5, Giardino N2, Favorite T1,2,6, Angstadt M2, Kessler D2, Welsh R1,7, Liberzon I1,2,3.

Increased connectivity between DMN and executive control regions following mindfulness training could underlie increased capacity for volitional shifting of attention. The increased PCC-DLPFC rsFC following MBET was related to PTSD symptom improvement, pointing to a potential therapeutic mechanism of mindfulness-based therapies.

https://www.ncbi.nlm.nih.gov/pubmed/27038410

Resting-state functional connectivity in major depressive disorder: A review.

Neurosci Biobehav Rev. 2015 Sep;56:330-44. doi: 10.1016/j.neubiorev.2015.07.014. Epub 2015 Jul 30.

Mulders PC1, van Eijndhoven PF2, Schene AH3, Beckmann CF4, Tendolkar I5.

Major depressive disorder (MDD) affects multiple large-scale functional networks in the brain, which has initiated a large number of studies on resting-state functional connectivity in depression. We review these recent studies using either seed-based correlation or independent component analysis and propose a model that incorporates changes in functional connectivity within current hypotheses of network-dysfunction in MDD. Although findings differ between studies, consistent findings include: (1) increased connectivity within the anterior default mode network, (2) increased connectivity between the salience network and the anterior default mode network, (3) changed connectivity between the anterior and posterior default mode network and (4) decreased connectivity between the posterior default mode network and the central executive network. These findings correspond to the current understanding of depression as a network-based disorder.

https://www.ncbi.nlm.nih.gov/pubmed/26234819

A Network-Based Neurobiological Model of PTSD: Evidence From Structural and Functional Neuroimaging Studies.

Curr Psychiatry Rep. 2017 Sep 19;19(11):81. doi: 10.1007/s11920-017-0840-4.

Akiki TJ1,2, Averill CL1,2, Abdallah CG3,4.

https://www.ncbi.nlm.nih.gov/pubmed/28924828

Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions.

https://www.ncbi.nlm.nih.gov/pubmed/25854674

Mindfulness research

In 1992 the Dalai Lama offered neuroscientist Richard Davidson, founder and director of the Center for Investigating Healthy Minds at the University of Wisconsin-Madison, the opportunity to scan brains of Tibetan monks to learn if years of cultivating well-being created changes in the brain. The monks had lifetime practices of mindfulness meditation with focus on compassion and loving kindness. Their functional MRIs showed very well-developed insula, the region of the brain that is activated by focus and attention on the body and on feelings. This finding also extends to the brains of those who have training in Mindfulness Based Stress Reduction, a program designed by Jon Kabat-Zinn (Davidson and Begley 2012).

(p. 42). from “Your Brain on Ink”