Research studies on patients’ illness experience using the Narrative Medicine approach: a systematic review.


The Impact of Psychological Stress on Wound Healing: Methods and Mechanisms

The Human Amygdala and Pain: Evidence from Neuroimaging

The amygdala, a small deep brain structure involved in behavioral processing through interactions with other brain regions, has garnered increased attention in recent years in relation to pain processing. As pain is a multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala is well suited to play a part in this process. Multiple neuroimaging studies of pain in humans have reported activation in the amygdala. Here we summarize these studies by performing a coordinate-based meta-analysis within experimentally induced and clinical pain studies using an activation likelihood estimate analysis. The results are presented in relation to locations of peak activation within and outside of amygdala subregions. The majority of studies identified coordinates consistent with human amygdala cytoarchitecture indicating reproducibility in neuroanatomical labeling across labs, analysis methods, and imaging modalities. Differences were noted between healthy and clinical pain studies: in clinical pain studies, peak activation was located in the laterobasal region, suggestive of the cognitive-affective overlay present among individuals suffering from chronic pain; while the less understood superficial region of the amygdala was prominent among experimental pain studies. Taken together, these findings suggest several important directions for further research exploring the amygdala’s role in pain processing.

Perseverate or decenter? Differential effects of metacognition on the relationship between parasympathetic inflexibility and symptoms of depression in a multi-wave study.

Behav Res Ther. 2017 Oct;97:123-133. doi: 10.1016/j.brat.2017.07.007. Epub 2017 Jul 17.

Stange JP1, Hamilton JL2, Fresco DM3, Alloy LB2.

Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks.

Psychosom Med. 2012 Nov-Dec;74(9):904-11. doi: 10.1097/PSY.0b013e318273bf33. Epub 2012 Oct 31.

Sripada RK1, King AP, Welsh RC, Garfinkel SN, Wang X, Sripada CS, Liberzon I.


Depress Anxiety. 2016 Apr;33(4):289-99. doi: 10.1002/da.22481.

King AP1,2, Block SR1,2,3, Sripada RK2,4, Rauch S5, Giardino N2, Favorite T1,2,6, Angstadt M2, Kessler D2, Welsh R1,7, Liberzon I1,2,3.

Increased connectivity between DMN and executive control regions following mindfulness training could underlie increased capacity for volitional shifting of attention. The increased PCC-DLPFC rsFC following MBET was related to PTSD symptom improvement, pointing to a potential therapeutic mechanism of mindfulness-based therapies.

Resting-state functional connectivity in major depressive disorder: A review.

Neurosci Biobehav Rev. 2015 Sep;56:330-44. doi: 10.1016/j.neubiorev.2015.07.014. Epub 2015 Jul 30.

Mulders PC1, van Eijndhoven PF2, Schene AH3, Beckmann CF4, Tendolkar I5.

Major depressive disorder (MDD) affects multiple large-scale functional networks in the brain, which has initiated a large number of studies on resting-state functional connectivity in depression. We review these recent studies using either seed-based correlation or independent component analysis and propose a model that incorporates changes in functional connectivity within current hypotheses of network-dysfunction in MDD. Although findings differ between studies, consistent findings include: (1) increased connectivity within the anterior default mode network, (2) increased connectivity between the salience network and the anterior default mode network, (3) changed connectivity between the anterior and posterior default mode network and (4) decreased connectivity between the posterior default mode network and the central executive network. These findings correspond to the current understanding of depression as a network-based disorder.